脂肪细胞命运与功能的微环境调控
Microenvironmental Control of Adipocyte Fate and Function.
作者信息
Pope Benjamin D, Warren Curtis R, Parker Kevin Kit, Cowan Chad A
机构信息
Disease Biophysics Group, Harvard Stem Cell Institute, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA; Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
出版信息
Trends Cell Biol. 2016 Oct;26(10):745-755. doi: 10.1016/j.tcb.2016.05.005. Epub 2016 Jun 4.
The properties of tissue-specific microenvironments vary widely in the human body and demonstrably influence the structure and function of many cell types. Adipocytes are no exception, responding to cues in specialized niches to perform vital metabolic and endocrine functions. The adipose microenvironment is remodeled during tissue expansion to maintain the structural and functional integrity of the tissue and disrupted remodeling in obesity contributes to the progression of metabolic syndrome, breast cancer, and other malignancies. The increasing incidence of these obesity-related diseases and the recent focus on improved in vitro models of human tissue biology underscore growing interest in the regulatory role of adipocyte microenvironments in health and disease.
组织特异性微环境的特性在人体中差异很大，并明显影响许多细胞类型的结构和功能。脂肪细胞也不例外，它们对特定微环境中的信号作出反应，以执行重要的代谢和内分泌功能。在组织扩张过程中，脂肪微环境会发生重塑，以维持组织的结构和功能完整性，而肥胖时重塑过程的紊乱会导致代谢综合征、乳腺癌和其他恶性肿瘤的进展。这些与肥胖相关疾病的发病率不断上升，以及最近对改进人体组织生物学体外模型的关注，凸显了人们对脂肪细胞微环境在健康和疾病中的调节作用越来越感兴趣。
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