State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Cells. 2022 Aug 8;11(15):2459. doi: 10.3390/cells11152459.
Cytoskeletal spectrin is found in (non)erythroid cells. Eukaryotic endocytosis takes place for internalizing cargos from extracellular milieu. The role of spectrin in endocytosis still remains poorly understood. Here, I summarize current knowledge of spectrin function, spectrin-based cytoskeleton and endocytosis of erythrocytes, and highlight how spectrin contributes to endocytosis and working models in different types of cells. From an evolutionary viewpoint, I discuss spectrin and endocytosis in a range of organisms, particularly in plants and yeast where spectrin is absent. Together, the role of spectrin in endocytosis is related to its post-translational modification, movement/rearrangement, elimination (by proteases) and meshwork fencing.
细胞骨架血影蛋白存在于（非）红细胞中。真核细胞通过胞吞作用将细胞外环境中的物质内化。然而，血影蛋白在胞吞作用中的作用仍知之甚少。本文总结了血影蛋白功能、基于血影蛋白的细胞骨架和红细胞胞吞作用的最新知识，并重点介绍了血影蛋白如何促进不同类型细胞的胞吞作用及其工作模型。从进化的角度来看，我讨论了在一系列生物，特别是在植物和酵母中不存在血影蛋白的生物中，血影蛋白和胞吞作用。总的来说，血影蛋白在胞吞作用中的作用与其翻译后修饰、运动/重排、消除（蛋白酶）和网格 fencing 有关。
