biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.
EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Nucleic Acids Res. 2021 Jan 8;49(D1):D458-D460. doi: 10.1093/nar/gkaa937.
SMART (Simple Modular Architecture Research Tool) is a web resource (https://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 9 contains manually curated models for more than 1300 protein domains, with a topical set of 68 new models added since our last update article (1). All the new models are for diverse recombinase families and subfamilies and as a set they provide a comprehensive overview of mobile element recombinases namely transposase, integrase, relaxase, resolvase, cas1 casposase and Xer like cellular recombinase. Further updates include the synchronization of the underlying protein databases with UniProt (2), Ensembl (3) and STRING (4), greatly increasing the total number of annotated domains and other protein features available in architecture analysis mode. Furthermore, SMART's vector-based protein display engine has been extended and updated to use the latest web technologies and the domain architecture analysis components have been optimized to handle the increased number of protein features available.
SMART（简单模块化架构研究工具）是一个网络资源（https://smart.embl.de），用于识别和注释蛋白质结构域以及分析蛋白质结构域架构。SMART 版本 9 包含了超过 1300 个蛋白质结构域的手动整理模型，自我们上次更新文章（1）以来，增加了一组 68 个新模型。所有新模型都是针对不同的重组酶家族和亚家族，作为一个整体，它们提供了移动元件重组酶的全面概述，即转座酶、整合酶、松弛酶、解离酶、cas1 casposase 和 Xer 样细胞重组酶。进一步的更新包括将底层蛋白质数据库与 UniProt（2）、Ensembl（3）和 STRING（4）同步，极大地增加了可用于架构分析模式的注释结构域和其他蛋白质特征的总数。此外，SMART 的基于向量的蛋白质显示引擎已得到扩展和更新，以使用最新的网络技术，并且域架构分析组件已进行了优化，以处理可用的大量蛋白质特征。
