Erdmann E, Höfling B
Dtsch Med Wochenschr. 1987 Jul 3;112(27):1067-72. doi: 10.1055/s-2008-1068195.
Percutaneous transfemoral valvuloplasty was performed in 20 patients (aged 25-83 years; mean 62) with marked signs of aortic valve stenosis, some calcified, others noncalcified. The transvalvar systolic pressure gradient was reduced from a mean of 104 +/- 7 mm Hg to a mean of 46 +/- 4 mm Hg, the valvar opening area from 0.38 +/- 0.04 cm2 to 0.74 +/- 0.04 cm2. The result was judged to be unsatisfactory in four patients and required aortic valve replacement after initially good results from the balloon dilatation. Serious complications were reversible ventricular fibrillation and reversible cerebral ischemia with partial hemiparesis in one patient each. In three patients the femoral artery had to be repaired at the site of puncture, twice the balloon ruptured without sequelae, once reversible pericardial effusion occurred, and twice there were reactions to antibiotics given after the procedure. Invasive re-catheterizations were performed in four patients, at intervals of three months: no increase in pressure gradient was observed. The results indicate that reduction of the transvalvar pressure gradient by 40 mm Hg can produce rapid reversal of heart failure and a symptom-free state even in patients who were already decompensated.
对20例有明显主动脉瓣狭窄体征(年龄25 - 83岁,平均62岁)的患者进行了经皮股动脉瓣膜成形术,部分患者瓣膜钙化,部分未钙化。跨瓣膜收缩压梯度从平均104±7 mmHg降至平均46±4 mmHg,瓣膜开口面积从0.38±0.04 cm²增至0.74±0.04 cm²。4例患者结果不理想,在球囊扩张最初效果良好后仍需进行主动脉瓣置换。严重并发症包括1例可逆性心室颤动和1例伴有部分偏瘫的可逆性脑缺血。3例患者在穿刺部位需修复股动脉,球囊破裂2次但无后遗症,发生1次可逆性心包积液,术后有2次对抗生素的反应。4例患者在3个月的间隔期内进行了有创再插管:未观察到压力梯度增加。结果表明,即使在已经失代偿的患者中,跨瓣膜压力梯度降低40 mmHg也可使心力衰竭迅速逆转并达到无症状状态。