College of Environmental Sciences, Sichuan Agricultural University, Chengdu 611130, China.
Environmental Science and Engineering, Guangdong Technion-Israel Institute of Technology, 241 Daxue Road, Shantou 515063, China.
Int J Environ Res Public Health. 2022 Jul 31;19(15):9405. doi: 10.3390/ijerph19159405.
Nanoparticles (NPs) are widely used and ubiquitous in the environment, but the consequences of their release into the environment on antibiotics resistance genes (ARGs), microbial abundance, and community, are largely unknown. Therefore, this study examined the effect of nano zero-valent iron (nZVI) and zinc oxide (nZnO) on tetracycline resistance genes (tet-ARGs) and class 1 integron () in sediment under laboratory incubation. The coexistence of NPs and tetracycline (TC) on tet-ARGs/ was also investigated. It was found that nZVI and nZnO promoted tet-ARGs/ abundance in sediment without TC but reduced the inducing effect of TC on tet-ARGs/ in sediment overlaid with TC solution. Without TC, nZVI, , and the bacterial community could directly promote tet-ARGs spread in nZVI sediment, while and bacterial abundance were the most directly important reasons for tet-ARGs spread in nZnO sediment. With TC, nZVI and bacterial community could reduce tet-ARGs abundance in nZVI sediment, while nZnO and bacterial community could directly promote tet-ARGs in nZnO sediment. Finally, these findings provided valuable information for understanding the role of NPs in promoting and reducing ARGs in the environment.
纳米颗粒（NPs）在环境中广泛应用且无处不在，但它们释放到环境中对抗生素抗性基因（ARGs）、微生物丰度和群落的影响在很大程度上是未知的。因此，本研究在实验室孵育条件下，考察了纳米零价铁（nZVI）和氧化锌（nZnO）对沉积物中四环素抗性基因（tet-ARGs）和类 1 整合子（）的影响。还研究了 NPs 和四环素（TC）共存对 tet-ARGs/的影响。结果发现，nZVI 和 nZnO 促进了 TC 不存在时沉积物中 tet-ARGs/的丰度，但降低了 TC 存在时 TC 对沉积物中 tet-ARGs/的诱导作用。在没有 TC 的情况下，nZVI、、和细菌群落可以直接促进 tet-ARGs 在 nZVI 沉积物中的传播，而 nZnO 沉积物中 tet-ARGs 传播的最直接重要原因是 和细菌丰度。有 TC 存在时，nZVI 和细菌群落可以降低 nZVI 沉积物中 tet-ARGs 的丰度，而 nZnO 和细菌群落可以直接促进 nZnO 沉积物中 tet-ARGs 的传播。最后，这些发现为理解 NPs 在促进和减少环境中 ARGs 方面的作用提供了有价值的信息。
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