Department of Basic Health Sciences, Preparatory Year, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Biology Department, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Int J Environ Res Public Health. 2022 Aug 7;19(15):9719. doi: 10.3390/ijerph19159719.
Rosinidin is a flavonoid anthocyanin pigmentation found in shrub flowers such as and . The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity induced by cisplatin in rats.
Oral acute toxicity tests of rosinidin were conducted to assess potential toxicity in animals, and it was shown to be safe. The nephroprotective effect of rosinidin 10, and 20 mg/kg were tested in rats for 25 days with concurrent administration of cisplatin. Several biochemical parameters were measured to support enzymatic and non-enzymatic oxidative stress such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH). Likewise, changes in several non-protein-nitrogenous components and blood chemistry parameters were made to support the theory linked with the pathogenesis of chemical-induced nephrotoxicity.
Cisplatin caused significant changes in biochemical, enzymatic, and blood chemistry, which rosinidin efficiently controlled.
The present investigation linked rosinidin with nephroprotective efficacy in experimental models.
山柰酚是一种类黄酮花色苷色素，存在于灌木花如 和 中。分子对接研究预测，山柰酚具有足够的结构能力，使其成为治疗多种疾病的可行药物候选物。本研究旨在评估山柰酚对顺铂诱导的大鼠肾毒性的肾保护作用。
进行了山柰酚的口服急性毒性试验，以评估动物的潜在毒性，结果表明其安全性良好。在 25 天的时间里，用顺铂同时给予山柰酚 10、20mg/kg，测试其对大鼠的肾保护作用。测量了几种生化参数，以支持超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH）等酶和非酶氧化应激。同样，也对几种非蛋白氮成分和血液化学参数的变化进行了研究，以支持与化学诱导性肾毒性发病机制相关的理论。
顺铂导致生化、酶和血液化学参数发生显著变化，而山柰酚有效地控制了这些变化。
本研究将山柰酚与实验模型中的肾保护作用联系起来。
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