Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 65 Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, SE-751 05 Uppsala, Sweden.
Int J Mol Sci. 2022 Jul 28;23(15):8371. doi: 10.3390/ijms23158371.
Ammonia loss from -asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of -asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases.
天冬酰胺残基的氨损失是一种非酶促反应，在所有蛋白质中自发发生，最终导致具有破坏性的异天冬氨酸残基，从而阻碍蛋白质功能并诱导与衰老相关的蛋白质病。在这里，我们讨论了支持完整修复反应可能性的理论考虑因素，并提出了其存在的第一个实验证据。如果得到证实，-天冬酰胺脱酰胺的真正修复可能为预防衰老和神经退行性疾病开辟新途径。
