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二酰甘油激酶在信号转导中的作用。

Diacylglycerol Kinases in Signal Transduction.

机构信息

Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy.

Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), University of Piemonte Orientale, 28100 Novara, Italy.

出版信息

Int J Mol Sci. 2022 Jul 29;23(15):8423. doi: 10.3390/ijms23158423.

DOI:10.3390/ijms23158423
PMID:35955558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9369165/
Abstract

In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase inhibitors [...].

摘要

近年来,在阐明 PI3K/AKT/mTOR 通路方面所做的大量研究工作促成了第一批基于脂质激酶抑制剂的靶向治疗药物的批准[...]。

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Diacylglycerol Kinases in Signal Transduction.二酰甘油激酶在信号转导中的作用。
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本文引用的文献

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AAV-delivered diacylglycerol kinase DGKk achieves long-term rescue of fragile X syndrome mouse model.腺相关病毒(AAV)递送的二酰基甘油激酶 DGKk 可实现脆性 X 综合征小鼠模型的长期挽救。
EMBO Mol Med. 2022 May 9;14(5):e14649. doi: 10.15252/emmm.202114649. Epub 2022 Apr 4.
2
Pediatric Atypical Hemolytic Uremic Syndrome Advances.儿科非典型溶血尿毒综合征的研究进展。
Cells. 2021 Dec 18;10(12):3580. doi: 10.3390/cells10123580.
3
Development of PI3K inhibitors: Advances in clinical trials and new strategies (Review).PI3K 抑制剂的研发:临床试验进展及新策略(综述)。
Pharmacol Res. 2021 Nov;173:105900. doi: 10.1016/j.phrs.2021.105900. Epub 2021 Sep 20.
4
Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1.X 连锁淋巴组织增生症 1 型中的二酰基甘油激酶 α。
Int J Mol Sci. 2021 May 29;22(11):5816. doi: 10.3390/ijms22115816.
5
Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.DGKγ 通过精确调控基础 PKCγ 活性对于运动协调至关重要。
Int J Mol Sci. 2020 Oct 23;21(21):7866. doi: 10.3390/ijms21217866.
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Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling.超越脂质信号:二酰基甘油激酶在细胞信号中的多效性作用。
Int J Mol Sci. 2020 Sep 18;21(18):6861. doi: 10.3390/ijms21186861.
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Int J Mol Sci. 2020 Sep 16;21(18):6794. doi: 10.3390/ijms21186794.
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