Department of Orthopedic Surgery, Gil Medical Center, College of Medicine, Gachon University, Incheon 21565, Korea.
Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Korea.
Int J Mol Sci. 2020 Sep 18;21(18):6861. doi: 10.3390/ijms21186861.
The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate phosphatidic acid signaling, regulates various signaling transductions in the mammalian cells. Studies on the regulation of diacylglycerol and phosphatidic acid levels by various enzymes, the identification and characterization of various diacylglycerol and phosphatidic acid-regulated proteins, and the overlap of different diacylglycerol and phosphatidic acid metabolic and signaling processes have revealed the complex and non-redundant roles of diacylglycerol kinases in regulating multiple biochemical and biological networks. In this review article, we summarized recent progress in the complex and non-redundant roles of diacylglycerol kinases, which is expected to aid in restoring dysregulated biochemical and biological networks in various pathological conditions at the bed side.
二酰基甘油激酶家族可以减弱二酰基甘油信号并激活磷酸脂酰肌醇信号，从而调节哺乳动物细胞中的各种信号转导。对各种酶调节二酰基甘油和磷酸脂酰肌醇水平、各种二酰基甘油和磷酸脂酰肌醇调节蛋白的鉴定和特性，以及不同二酰基甘油和磷酸脂酰肌醇代谢和信号过程的重叠的研究，揭示了二酰基甘油激酶在调节多个生化和生物学网络中的复杂和非冗余作用。在这篇综述文章中，我们总结了二酰基甘油激酶的复杂和非冗余作用的最新进展，有望在床边帮助恢复各种病理条件下失调的生化和生物学网络。
