Colombian Nephrology Association, Bogotá 110221, Colombia.
Management of Technologies and Innovation, Department of Engineering, Universidad Simón Bolivar, Cl. 58 #55-132, Barranquilla 080002, Colombia.
Int J Mol Sci. 2022 Aug 4;23(15):8668. doi: 10.3390/ijms23158668.
The inflammatory component of diabetic kidney disease has become of great interest in recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components such as the complement system also play a role, as well as specific cytokines and chemokines. The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets.
近年来，糖尿病肾病的炎症成分引起了极大的关注，遗传和表观遗传变异在疾病的发生和发展中起着根本作用。先天免疫系统的细胞在糖尿病肾病的发病机制中起着主要作用，适应性免疫细胞的作用较小。其他成分，如补体系统，以及特定的细胞因子和趋化因子也发挥作用。糖尿病肾病的炎症成分是一个非常有趣的研究领域，也是一个活跃的研究领域，希望能找到有潜力的创新治疗靶点。
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