3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Department of Medical Biology, School of Medicine, Yeditepe University, 34755 Istanbul, Turkey.
Int J Mol Sci. 2022 Aug 4;23(15):8672. doi: 10.3390/ijms23158672.
Vascular aging, characterized by structural and functional alterations of the vascular wall, is a hallmark of aging and is tightly related to the development of cardiovascular mortality and age-associated vascular pathologies. Over the last years, extensive and ongoing research has highlighted several sophisticated molecular mechanisms that are involved in the pathophysiology of vascular aging. A more thorough understanding of these mechanisms could help to provide a new insight into the complex biology of this non-reversible vascular process and direct future interventions to improve longevity. In this review, we discuss the role of the most important molecular pathways involved in vascular ageing including oxidative stress, vascular inflammation, extracellular matrix metalloproteinases activity, epigenetic regulation, telomere shortening, senescence and autophagy.
血管衰老，其特征是血管壁的结构和功能改变，是衰老的一个标志，与心血管死亡率和与年龄相关的血管病变的发展密切相关。在过去的几年中，广泛而持续的研究强调了几种复杂的分子机制，这些机制涉及血管衰老的病理生理学。更深入地了解这些机制可以帮助我们更深入地了解这一不可逆转的血管过程的复杂生物学，并指导未来的干预措施以提高寿命。在这篇综述中，我们讨论了参与血管老化的最重要的分子途径的作用，包括氧化应激、血管炎症、细胞外基质金属蛋白酶活性、表观遗传调控、端粒缩短、衰老和自噬。
