特应性皮炎的代谢组学研究进展概述及研究方向展望

An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study.

机构信息

Department of Environmental Medicine, Medical Faculty, University Augsburg, 86156 Augsburg, Germany.

Chair of Analytical Food Chemistry, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.

出版信息

Int J Mol Sci. 2022 Aug 8;23(15):8791. doi: 10.3390/ijms23158791.

DOI:10.3390/ijms23158791

PMID:35955924

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9368995/

Abstract

Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin.

摘要

特应性皮炎（AE）是一种炎症性皮肤疾病，影响全球约 20%的儿童，疾病早期发作可导致哮喘和过敏。目前，该疾病的发病机制尚未完全阐明。代谢组学是对宿主和微生物产生的皮肤中小分子的分析，为观察疾病机制提供了一个窗口，从而可能为 AE 的治疗提供新的药物靶点。本文综述了 AE 代谢组学的最新进展，重点介绍了脂类和非脂类分子，并综述了目前已知存在于皮肤中的代谢物。