Graduate School, Hasanuddin University, Makassar 90245, Indonesia.
IMERI Faculty of Medicine, Human Genetic Research Cluster, Universitas Indonesia, Jakarta 10430, Indonesia.
Nutrients. 2022 Nov 4;14(21):4676. doi: 10.3390/nu14214676.
Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the gene cluster. Among 390 infants of the Indonesian ISADI study, GPL-FA were measured in umbilical plasma (P-0y) and in buccal cells at birth (B-0y), and again in buccal cells at AD onset or one year (B-1y). Prospective and cross-sectional associations with AD were assessed by logistic regression. Interactions of GPL-FA with 14 SNP were tested assuming an additive model. AD was diagnosed in 15.4% of participants. In B-1y, C18:2n-6 was inversely associated with AD; and positive associations were observed for C18:1n-9, C20:4n-6, C22:6n-3 and C20:4n-6/C18:2n-6. There were no prospective associations with AD, however, a significant interaction between the SNP rs174449 and B-0y C14:0 (myristic acid) was observed. This study indicates that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production, as well as higher C18:1n-9 levels. GPL-FA measured at birth do not predict later AD incidence; however, genotype interactions reveal novel effects of myristic acid, which are modified by a variant.
脂肪酸发挥着一系列不同的生物学活性，这些活性可能与特应性皮炎（AD）的发展有关。本研究调查了甘油磷脂脂肪酸（GPL-FA）与 AD 的关联，以及它们与基因簇的单核苷酸多态性（SNP）的相互作用。在印度尼西亚 ISADI 研究的 390 名婴儿中，在脐带血浆（P-0y）和出生时的口腔细胞（B-0y）中测量了 GPL-FA，并在 AD 发作或一年时再次在口腔细胞（B-1y）中测量。通过逻辑回归评估了与 AD 的前瞻性和横断面关联。假设加性模型，测试了 GPL-FA 与 14 个 SNP 的相互作用。在参与者中，15.4%被诊断为 AD。在 B-1y 中，C18:2n-6 与 AD 呈负相关；C18:1n-9、C20:4n-6、C22:6n-3 和 C20:4n-6/C18:2n-6 呈正相关。然而，与 AD 没有前瞻性关联，但观察到 SNP rs174449 与 B-0y C14:0（肉豆蔻酸）之间存在显著的相互作用。本研究表明，患有 AD 的印度尼西亚婴儿体内内源性长链多不饱和脂肪酸的产生率增加，C18:1n-9 水平升高。出生时测量的 GPL-FA 不能预测以后 AD 的发病率；然而，基因型相互作用揭示了肉豆蔻酸的新作用，其受一个变体的修饰。
