Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Academy for Advanced Interdisciplinary Studies, Henan University, Kaifeng 475004, China.
Department of Anesthesia, Stanford University, Stanford, CA 94305, USA.
Int J Mol Sci. 2022 Aug 8;23(15):8799. doi: 10.3390/ijms23158799.
Blood group antigen is a class of heritable antigenic substances present on the erythrocyte membrane. However, the role of blood group antigens in cancer prognosis is still largely unclear. In this study, we investigated the expression of 33 blood group antigen genes and their association with the prognosis of 30 types of cancers in 31,870 tumor tissue samples. Our results revealed that blood group antigens are abnormally expressed in a variety of cancers. The high expression of these antigen genes was mainly related to the activation of the epithelial-mesenchymal transition (EMT) pathway. High expression of seven antigen genes, i.e., , , , , , and , were significantly associated with good OS (Overall Survival) in six types of cancers, while ten genes, i.e., , , , , , , , , , and , were associated with poor OS in three types of cancers. Kidney renal clear cell carcinoma (KIRC) is associated with the largest number (14 genes) of prognostic antigen genes, i.e., , , , , , , , , , , , , , and . High expression of gene was significantly correlated with a poor prognosis of KIRC in this analysis but has not been reported previously. might be a putative biomarker for poor prognosis in KIRC. In conclusion, our analysis indicates that blood group antigens may play functional important roles in tumorigenesis, progression, and especially prognosis. These results provide data to support prognostic marker development and future clinical management.
血型抗原是一类存在于红细胞膜上的遗传性抗原物质。然而，血型抗原在癌症预后中的作用在很大程度上仍不清楚。在这项研究中，我们研究了 33 个血型抗原基因的表达及其与 31870 个肿瘤组织样本中 30 种癌症的预后的关系。我们的结果表明，血型抗原在多种癌症中表达异常。这些抗原基因的高表达主要与上皮-间充质转化（EMT）途径的激活有关。七种抗原基因（即、、、、、、和）的高表达与六种癌症的良好 OS（总体生存率）显著相关，而十个基因（即、、、、、、、、和）与三种癌症的不良 OS 相关。肾透明细胞癌（KIRC）与预后抗原基因数量最多（14 个）相关，即、、、、、、、、、、和。在这项分析中，基因的高表达与 KIRC 的不良预后显著相关，但以前没有报道过。可能是 KIRC 不良预后的一个潜在生物标志物。总之，我们的分析表明，血型抗原可能在肿瘤发生、进展、特别是预后中发挥重要的功能作用。这些结果为预后标志物的开发和未来的临床管理提供了数据支持。
