Rogers P H, Walsh P N, Marder V J, Bosak G C, Lachman J W, Ritchie W G, Oppenheimer L, Sherry S
J Bone Joint Surg Am. 1978 Sep;60(6):758-62.
A randomized, double-blind controlled trial of low-dose heparin combined with sulfinpyrazone to prevent deep-vein thrombosis after operation on the hip was carried out. In a group of seventy-three patients after arthroplasty, postoperative thrombosis of the veins of the lower limbs occurred in 51 per cent of the control patients and in 36 per cent of the treated patients. In a fracture group of thirty patients, thrombosis occurred in 75 per cent of the control patients and in 36 per cent of the treated patients. These differences are of borderline statistical significance in the fracture group and are of no statistical significance in the arthroplasty group. However, a 36 per cent incidence of venous thrombosis in the drug-treated patients is too high to justify recommendation of the regimen tested without careful monitoring of patients by tests designed to detect thrombosis. Then, appropriate anticoagulant therapy can be instituted if necessary.
开展了一项低剂量肝素联合磺吡酮预防髋关节手术后深静脉血栓形成的随机双盲对照试验。在一组73例关节置换术后患者中，对照组下肢静脉血栓形成发生率为51%，治疗组为36%。在30例骨折患者组中，对照组血栓形成发生率为75%，治疗组为36%。这些差异在骨折组具有临界统计学意义，在关节置换组无统计学意义。然而，药物治疗患者中36%的静脉血栓形成发生率过高，在没有通过旨在检测血栓形成的试验对患者进行仔细监测的情况下，无法证明所测试方案的推荐合理性。然后，如有必要可进行适当的抗凝治疗。
