Swiss Nutrition and Health Foundation, 1066 Epalinges, Switzerland.
Division of Primary Care Medicine, Department of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Nutrients. 2022 Aug 3;14(15):3185. doi: 10.3390/nu14153185.
The association between vitamin D and weight gain remains controversial due to important limitations in the studies. We investigated the relationship between vitamin D levels and 5 and 10 years of weight and waist circumference change in a population-based prospective cohort study.
Prospective study including participants aged between 35 and 75 years living in the city of Lausanne, Switzerland. Weight and waist change at 5- and 10-year follow-up were assessed according to baseline vitamin D status (normal, insufficiency and deficiency).
A total of 3638 participants (47.9 % women, mean age 51.6 ± 10.4 years) were included for the 5-year follow-up. No association was found between vitamin D categories and weight change, multivariate-adjusted average ± standard error: 1.6 ± 0.3, 1.5 ± 0.2 and 1.2 ± 0.1 kg for normal, insufficiency and deficiency, respectively, = 0.159. For waist change, the corresponding values were 3.3 ± 0.4, 3.3 ± 0.2 and 3.4 ± 0.2 cm, = 0.792. For the 10-year follow-up, data from 2999 participants (45.8% women, mean age 50.8 ± 10.3 years) were used. No association was found for weight 2.3 ± 0.4, 2.3 ± 0.2 and 2.0 ± 0.2 kg, = 0.588, or for waist 3.7 ± 0.4, 3.6 ± 0.3 and 4.2 ± 0.2 cm for normal, insufficiency and deficiency, respectively, = 0.259.
No association between vitamin D status and weight or waist gain at 5- and 10-year follow-up was found.
由于研究中的重要限制，维生素 D 与体重增加之间的关联仍然存在争议。我们在一项基于人群的前瞻性队列研究中调查了维生素 D 水平与 5 年和 10 年体重和腰围变化的关系。
这项前瞻性研究包括居住在瑞士洛桑市的 35 至 75 岁的参与者。根据基线维生素 D 状况（正常、不足和缺乏）评估 5 年和 10 年随访时的体重和腰围变化。
共有 3638 名参与者（47.9%为女性，平均年龄 51.6 ± 10.4 岁）参加了 5 年随访。维生素 D 类别与体重变化之间没有关联，多变量调整后的平均 ± 标准误差：正常、不足和缺乏分别为 1.6 ± 0.3、1.5 ± 0.2 和 1.2 ± 0.1 公斤， = 0.159。对于腰围变化，相应的值分别为 3.3 ± 0.4、3.3 ± 0.2 和 3.4 ± 0.2 厘米， = 0.792。对于 10 年随访，使用了 2999 名参与者（45.8%为女性，平均年龄 50.8 ± 10.3 岁）的数据。对于体重，没有发现关联，2.3 ± 0.4、2.3 ± 0.2 和 2.0 ± 0.2 公斤， = 0.588，或者对于腰围，正常、不足和缺乏的分别为 3.7 ± 0.4、3.6 ± 0.3 和 4.2 ± 0.2 厘米， = 0.259。
在 5 年和 10 年随访时，维生素 D 状况与体重或腰围增加之间没有关联。
