腹型肥胖（基于腰围）与血清维生素 D 水平的关系：系统评价和流行病学研究的荟萃分析。

Relationship between abdominal obesity (based on waist circumference) and serum vitamin D levels: a systematic review and meta-analysis of epidemiologic studies.

机构信息

Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Nutr Rev. 2022 Apr 8;80(5):1105-1117. doi: 10.1093/nutrit/nuab070.

DOI:10.1093/nutrit/nuab070

PMID:34537844

Abstract

CONTEXT

Although previous observational studies have investigated the association between waist circumference (WC) values and serum vitamin D levels, findings have been inconsistent.

OBJECTIVE

A systematic review and meta-analysis was performed to evaluate the effect of abdominal obesity (based on WC) on vitamin D deficiency or insufficiency in adults.

DATA SOURCES

A systematic search of the published literature up to September 2020 was conducted in electronic databases, including MEDLINE (PubMed), EMBASE, Institute for Scientific Information (ISI) (Web of Science), Scopus, and Google Scholar, for observational studies that investigated the association between abdominal obesity (based on WC) or different categories of WC as the exposure and serum 25-hydroxy vitamin D levels as the outcome.

DATA EXTRACTION

Eighteen cross-sectional studies were included in the review. The relationship between WC values and combined serum vitamin D deficiency and insufficiency (<30 ng/mL) or vitamin D deficiency (<20 ng/mL) was evaluated.

DATA ANALYSIS

Combining 8 effect sizes from 5 investigations, including 7997 individuals, illustrated that the highest category of WC, compared with the lowest category of WC, was related to 82% increased odds of combined serum vitamin D deficiency and insufficiency (<30 ng/mL) (OR: 1.82; 95% CI: 1.34, 2.49). Moreover, in studies that investigated both genders together, the highest category of WC, compared with the lowest category of WC, was associated with 61% increased odds of serum vitamin D deficiency (<20 ng/mL) (OR: 1.61; 95% CI: 1.12, 2.31). The same results were obtained for almost all subgroups for several covariates.

CONCLUSION

This meta-analysis of cross-sectional studies confirmed that increased WC was related to the elevated risk of combined vitamin D deficiency and insufficiency in adults. More prospective studies are needed to confirm causality.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO registration no. CRD42020190485.

摘要

背景

尽管先前的观察性研究已经探讨了腰围（WC）值与血清维生素 D 水平之间的关系，但结果并不一致。

目的

进行了一项系统评价和荟萃分析，以评估基于 WC 的腹部肥胖对成年人维生素 D 缺乏或不足的影响。

数据来源

系统检索了截至 2020 年 9 月的已发表文献，检索电子数据库包括 MEDLINE（PubMed）、EMBASE、科学信息研究所（ISI）（Web of Science）、Scopus 和 Google Scholar，以寻找调查基于 WC 的腹部肥胖（WC）或 WC 不同类别作为暴露，血清 25-羟维生素 D 水平作为结局的观察性研究。

数据提取

本综述纳入了 18 项横断面研究。评估了 WC 值与综合血清维生素 D 缺乏和不足（<30ng/ml）或维生素 D 缺乏（<20ng/ml）之间的关系。

数据分析

合并 5 项研究中的 8 个效应量，包括 7997 人，结果表明，与最低 WC 类别相比，最高 WC 类别与综合血清维生素 D 缺乏和不足（<30ng/ml）的几率增加 82%（OR：1.82；95%CI：1.34，2.49）。此外，在同时研究男女的研究中，与最低 WC 类别相比，最高 WC 类别与血清维生素 D 缺乏（<20ng/ml）的几率增加 61%（OR：1.61；95%CI：1.12，2.31）。对于几个协变量的几乎所有亚组，都得到了相同的结果。