Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Santa Maria della Misericordia Hospital, 06132 Perugia, Italy.
Division of Clinical Geriatrics, NVS Department, Karolinska Institutet Stockholm, 171 77 Stockholm, Sweden.
Nutrients. 2022 Aug 7;14(15):3228. doi: 10.3390/nu14153228.
Inflammation, along with aging processes, contributes to the development of insulin resistance (IR), but the roles of different inflammatory and other cytokines in this process remain unclear. Thus, we aimed to analyze the association between several plasma cytokines with IR as evaluated by the metabolic score for insulin resistance, METS-IR.
We measured the plasma concentrations of thirty cytokines from a cohort of older persons and analyzed their role as independent factors for IR. We used regression analyses adjusted for known IR-associated factors (including age, gender, cholesterol levels, and BMI) to find the determinants of IR.
The study evaluated 132 subjects, mostly women (82F/50M), slightly overweight, and with a mean age of 78.5 ± 6.5 years. In the overall population, IL-15 significantly and negatively correlates with METS-IR (r = -0.183, = 0.036). A regression model showed that the association between IL-15 and METS-IR was significantly modulated by gender and BMI (R: 0.831). Only in women, EGF, Eotaxin and MCP-1 significantly correlated with METS-IR even after controlling by age (EGF, r = 0.250 = 0.025; Eotaxin, r = 0.276 = 0.13; MCP-1, r = 0.237, = 0.033). Furthermore, regression models showed that these molecules were associated with METS-IR and were strongly mediated by BMI.
Our results indicate the association between cytokines and IR has to be interpreted in a gender-specific manner. In women, EGF, Eotaxin, and MCP-1 circulating levels are associated with METS-IR being BMI a significant mediator. Understanding the role of gender in the relationship between cytokines and IR will help to define individualized preventive and treatment interventions to reduce the risk of age-related metabolic disorders.
炎症与衰老过程一起导致胰岛素抵抗（IR）的发展，但不同炎症和其他细胞因子在这一过程中的作用仍不清楚。因此，我们旨在分析几种血浆细胞因子与通过代谢评分胰岛素抵抗（METS-IR）评估的 IR 之间的关联。
我们测量了一组老年人的血浆细胞因子浓度，并分析了它们作为 IR 独立因素的作用。我们使用回归分析调整了已知与 IR 相关的因素（包括年龄、性别、胆固醇水平和 BMI），以确定 IR 的决定因素。
该研究评估了 132 名受试者，主要是女性（82 名女性/50 名男性），体重略超重，平均年龄为 78.5 ± 6.5 岁。在整个人群中，IL-15 与 METS-IR 呈显著负相关（r = -0.183， = 0.036）。回归模型显示，IL-15 与 METS-IR 之间的关联受性别和 BMI 显著调节（R：0.831）。仅在女性中，EGF、Eotaxin 和 MCP-1 与 METS-IR 显著相关，即使在控制年龄后也是如此（EGF，r = 0.250， = 0.025；Eotaxin，r = 0.276， = 0.13；MCP-1，r = 0.237， = 0.033）。此外，回归模型表明，这些分子与 METS-IR 相关，并且受 BMI 强烈介导。
我们的结果表明，细胞因子与 IR 之间的关联必须以性别特异性的方式进行解释。在女性中，EGF、Eotaxin 和 MCP-1 的循环水平与 METS-IR 相关，而 BMI 是一个重要的中介。了解性别在细胞因子与 IR 之间的关系中的作用将有助于确定个性化的预防和治疗干预措施，以降低与年龄相关的代谢紊乱的风险。
