Lacan Ioana, Moldovan Mărioara, Sarosi Codruța, Ardelean Ioan
Department of Physics and Chemistry, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania.
Department of Polymer Composites, "Raluca Ripan" Chemistry Research Institute, "Babes-Bolyai" University, 400294 Cluj-Napoca, Romania.
Polymers (Basel). 2022 Jul 27;14(15):3042. doi: 10.3390/polym14153042.
Calcium phosphate cements are used in dentistry and orthopedics to repair and reconstruct bone defects. The properties of these bone cements can be improved by introducing additives into their composition. One favorable additive is chitosan, which can be beneficial but can also cause considerable damage if it has a high load, thus, limiting its clinical applicability and performance. That is why understanding chitosan's role in cement composition is an important issue when developing new materials. The present work uses low-field nuclear magnetic resonance (NMR) relaxometry to investigate the effect introduced by the addition of chitosan on the hardening process of calcium phosphate cement. Two samples, prepared with and without chitosan, were comparatively investigated during the first six minutes of hardening. The liquid evolution inside these samples was monitored using transverse relaxation time distributions. It demonstrated an acceleration effect on the hardening dynamics introduced by the presence of chitosan. Furthermore, it was shown that even after one hour of hardening, there were still unreacted monomers inside the bone cement and their amount was reduced in the presence of chitosan.
磷酸钙骨水泥用于牙科和骨科领域，以修复和重建骨缺损。通过在其成分中引入添加剂，可以改善这些骨水泥的性能。一种有利的添加剂是壳聚糖，它可能有益，但如果负载量高也会造成相当大的损害，因此限制了其临床适用性和性能。这就是为什么在开发新材料时，了解壳聚糖在骨水泥成分中的作用是一个重要问题。目前的工作使用低场核磁共振（NMR）弛豫测量法来研究添加壳聚糖对磷酸钙骨水泥硬化过程的影响。制备了添加壳聚糖和未添加壳聚糖的两个样品，并在硬化的前六分钟进行了对比研究。使用横向弛豫时间分布监测这些样品内部的液体演变。结果表明壳聚糖的存在对硬化动力学有加速作用。此外，研究表明，即使在硬化一小时后，骨水泥中仍存在未反应的单体，而在壳聚糖存在的情况下，其数量有所减少。
