Applied Biophysics and Food Research Center (Centro de Investigaciones en Biofisica Aplicada y Alimentos, CIBAAL, Laboratory of Biointerphases and Biomimetic Systems, National University of Santiago del Estero and CONICET), RN 9-Km 1125, Santiago del Estero 4206, Argentina.
Molecules. 2022 Aug 5;27(15):4994. doi: 10.3390/molecules27154994.
This review is an attempt to incorporate water as a structural and thermodynamic component of biomembranes. With this purpose, the consideration of the membrane interphase as a bidimensional hydrated polar head group solution, coupled to the hydrocarbon region allows for the reconciliation of two theories on cells in dispute today: one considering the membrane as an essential part in terms of compartmentalization, and another in which lipid membranes are not necessary and cells can be treated as a colloidal system. The criterium followed is to describe the membrane state as an open, non-autonomous and responsive system using the approach of Thermodynamic of Irreversible Processes. The concept of an open/non-autonomous membrane system allows for the visualization of the interrelationship between metabolic events and membrane polymorphic changes. Therefore, the Association Induction Hypothesis (AIH) and lipid properties interplay should consider hydration in terms of free energy modulated by water activity and surface (lateral) pressure. Water in restricted regions at the lipid interphase has thermodynamic properties that explain the role of H-bonding networks in the propagation of events between membrane and cytoplasm that appears to be relevant in the context of crowded systems.
这篇综述试图将水纳入生物膜的结构和热力学组成部分。为此，将膜相间视为二维水合极性头基溶液与烃区耦合，使得当今有争议的两种关于细胞的理论得以调和：一种理论认为膜在分隔方面是必不可少的，另一种理论则认为脂质膜并非必需，细胞可以视为胶体体系。遵循的标准是使用不可逆过程热力学的方法，将膜状态描述为开放、非自主和响应性系统。开放/非自主膜系统的概念允许可视化代谢事件和膜多态性变化之间的相互关系。因此，缔合诱导假说（AIH）和脂质特性相互作用应该考虑水合作用，即由水活度和表面（横向）压力调制的自由能。在脂质相间的受限区域内的水具有热力学性质，可以解释氢键网络在膜和细胞质之间传播事件的作用，这在拥挤系统的背景下似乎是相关的。
