Disalvo E Anibal
Laboratorio de Biointerfases y Sistemas Biomimeticos, Centro de Investigacion y Transferencia de Santiago del Estero, Universidad Nacional de Santiago del Estero-Consejo Nacional de Investigaciones Científicas y Técnicas, 4200, Santiago del Estero, Argentina.
Subcell Biochem. 2015;71:1-16. doi: 10.1007/978-3-319-19060-0_1.
The classical view of a biological membrane is based on the Singer-Nicholson mosaic fluid model in which the lipid bilayer is the structural backbone. Under this paradigm, many studies of biological processes such as, permeability, active transport, enzyme activity and adhesion and fusion processes have been rationalized considering the lipid membrane as a low dielectric slab of hydrocarbon chains with polar head groups exposed to water at each side in which oil/water partition prevails. In spite of several analyses and evidence available in relation to membrane hydration, water is not taken into account as a functional component. For this purpose, new insights in the water organization in restricted environments and the thermodynamical and mechanical properties emerging from them are specifically analysed and correlated.This chapter summarizes the progress of the studies of water in membranes along the book in order to give a more realistic structural and dynamical picture accounting for the membrane functional properties.
生物膜的经典观点基于辛格-尼科尔森镶嵌流体模型，其中脂质双层是结构骨架。在这种范式下，许多关于生物过程的研究，如通透性、主动运输、酶活性以及黏附与融合过程，都将脂质膜视为烃链的低介电平板，其极性头部基团在两侧暴露于水中，且存在油/水分配现象，从而得到了合理的解释。尽管有若干关于膜水合作用的分析和证据，但水并未被视为一种功能成分。为此，本文专门分析并关联了受限环境中水的组织以及由此产生的热力学和力学性质方面的新见解。本章总结了全书关于膜中水的研究进展，以便给出一个更能体现膜功能特性的现实结构和动力学图景。
