Stewart D J, Münzel T, Bassenge E
Eur J Pharmacol. 1987 Apr 14;136(2):239-42. doi: 10.1016/0014-2999(87)90717-5.
In large arteries, acetylcholine-induced dilation is mediated by endothelium-derived relaxing factor (EDRF) and can be blocked by hemoglobin (Hb). However, the role of EDRF in the microcirculation is uncertain. Therefore, the effect of Hb on acetylcholine-induced dilation of resistance vessels was studied in isolated, constant-flow perfused rabbit hearts. Hb reversibly blocked the acetylcholine-induced lowering of perfusion pressure (control -27 +/- 3%; during Hb 0 +/- 4%) without inhibiting responses to other dilators, strongly suggesting that acetylcholine action in the microcirculation is mediated by EDRF.
在大动脉中，乙酰胆碱诱导的血管舒张由内皮衍生舒张因子（EDRF）介导，且可被血红蛋白（Hb）阻断。然而，EDRF在微循环中的作用尚不确定。因此，在离体、恒流灌注的兔心脏中研究了Hb对乙酰胆碱诱导的阻力血管舒张的影响。Hb可逆性地阻断了乙酰胆碱诱导的灌注压降低（对照时降低27±3%；加入Hb时降低0±4%），同时不抑制对其他舒张剂的反应，强烈提示微循环中乙酰胆碱的作用由EDRF介导。
