BM 14.478对豚鼠乳头肌去表皮心肌纤维的钙敏化作用。
Ca2+-sensitizing effect of BM 14.478 on skinned cardiac muscle fibres of guinea-pig papillary muscle.
作者信息
Freund P, Müller-Beckmann B, Strein K, Kling L, Rüegg J C
出版信息
Eur J Pharmacol. 1987 Apr 14;136(2):243-6. doi: 10.1016/0014-2999(87)90718-7.
A concentration-dependent increase in force development was obtained with BM 14.478 (10(-9)-5 X 10(-4) M) in skinned fibres of guinea-pig papillary muscles. Guinea-pig papillary muscles are standard preparations for evaluating inotropic effects and they were also used in the present case for evaluating the positive inotropic effect of BM 14.478. We therefore conclude that a marked calcium-sensitizing effect contributes to the positive inotropic effect obtained with BM 14.478 even at very low concentrations.
在豚鼠乳头肌的去皮肤纤维中，BM 14.478（10⁻⁹ - 5×10⁻⁴ M）可引起肌力发展呈浓度依赖性增加。豚鼠乳头肌是评估变力作用的标准标本，在本研究中也用于评估BM 14.478的正性变力作用。因此我们得出结论，即使在非常低的浓度下，显著的钙敏化效应也有助于BM 14.478产生正性变力作用。
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