猫、兔和豚鼠离体心肌对氨力农的反应。

Responses to amrinone in isolated cardiac muscles from cat, rabbit, and guinea pig.

作者信息

Siegl P K, Morgan G, Sweet C S

出版信息

J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):281-7. doi: 10.1097/00005344-198403000-00012.

DOI:10.1097/00005344-198403000-00012

PMID:6200717

Abstract

Amrinone (10(-5)-10(-2) M) produced a positive inotropic response in several electrically stimulated, isolated cardiac muscle preparations. The order of potencies for amrinone in the tissues studied was: cat papillary muscle greater than rabbit papillary muscle greater than muscle strips from rabbit left atria = guinea pig papillary muscle greater than guinea pig left atria. Amrinone also restored contractility to cat and rabbit papillary muscles which had been partially depolarized with 20 mM K+. The beta-adrenergic antagonists timolol and propranolol partially inhibited these responses in rabbit but not cat papillary muscles. Reserpine pretreatment did not influence the responses to amrinone in any of the preparations studied. In conclusion, (a) the cat papillary muscle was the most sensitive preparation to the inotropic effect of amrinone, and (b) in the rabbit papillary muscle, beta-adrenoceptors contribute to the amrinone response but are not solely responsible for the enhanced inotropy.

摘要

氨力农（10⁻⁵ - 10⁻² M）在几种经电刺激的离体心肌制备物中产生了正性肌力反应。在所研究的组织中，氨力农的效能顺序为：猫乳头肌＞兔乳头肌＞兔左心房肌条 = 豚鼠乳头肌＞豚鼠左心房。氨力农还使已用20 mM K⁺部分去极化的猫和兔乳头肌的收缩力恢复。β - 肾上腺素能拮抗剂噻吗洛尔和普萘洛尔部分抑制了兔乳头肌而非猫乳头肌的这些反应。利血平预处理对所研究的任何制备物中氨力农的反应均无影响。总之，（a）猫乳头肌是对氨力农正性肌力作用最敏感的制备物，且（b）在兔乳头肌中，β - 肾上腺素能受体对氨力农反应有贡献，但并非增强心肌收缩力的唯一原因。