Green D P
J Cell Sci. 1978 Aug;32:137-51. doi: 10.1242/jcs.32.1.137.
The divalent metal cation ionophore A23187 induces an acrosome reaction in guinea-pig sperm which is dependent on external calcium. Examination of this acrosome reaction by electron microscopy shows that it is morphologically normal. The known properties of A23187 and the morphological similarity between the acrosome reaction and the secretory discharges of other secretory cells suggests that the immediate cause of the acrosome reaction is an increase in the cytoplasmic free calcium concentration.
二价金属阳离子载体A23187可诱导豚鼠精子发生顶体反应，该反应依赖于细胞外钙。通过电子显微镜对这种顶体反应进行检查，结果表明其在形态上是正常的。A23187的已知特性以及顶体反应与其他分泌细胞分泌释放之间的形态学相似性表明，顶体反应的直接原因是细胞质游离钙浓度的增加。
