离子载体A23187可诱导海胆和豚鼠精子发生顶体反应。
Ionophore A23187 induces acrosome reactions in sea urchin and guinea pig spermatozoa.
作者信息
Summers R G, Talbot P, Keough E M, Hylander B L, Franklin L E
出版信息
J Exp Zool. 1976 Jun;196(3):381-5. doi: 10.1002/jez.1401960312.
PMID:932665
Abstract
Ionophore A23187, in the presence of extracellular Ca+2, induces a morphologically normal acrosome reaction in sperm of the sea urchin and precocious acrosome reaction and activation of guinea pig sperm. Increased membrane permeability to Ca+2 is responsible for initiating the acrosome reaction in both sea urchin and guinea pig sperm. In sea urchin sperm, the permeability change is brought about by egg jelly, whereas in the guinea pig sperm it accompanies capacitation.
摘要
离子载体A23187在细胞外Ca+2存在的情况下，可诱导海胆精子发生形态正常的顶体反应，以及豚鼠精子的早熟顶体反应和激活。膜对Ca+2通透性的增加是引发海胆和豚鼠精子顶体反应的原因。在海胆精子中，通透性变化是由卵胶引发的，而在豚鼠精子中，通透性变化伴随着获能过程。
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