Iwata K, Itoga H, Muramatsu H, Toda K, Sumino R
Exp Brain Res. 1987;66(2):435-9. doi: 10.1007/BF00243318.
The properties of single cortical neurons responding to electrical stimulation of the tooth-pulp and to intrapulpal application of bradykinin were studied in the cat. The activities of tooth-pulp driven neurons (TPNs) were recorded from the middle and anterior parts of the coronal gyrus of the cerebral cortex. Bradykinin-sensitive tooth-pulp driven neurons (BK-TPNs) were located in layer IV of area 3b of the anterior part of the coronal gyrus. These neurons had a large cutaneous oro-facial receptive field and received a nociceptive input from the facial skin as well as from the tooth-pulp. The BK-TPNs had a higher threshold and longer latency to electrical stimulation than TPNs insensitive to bradykinin (non BK-TPNs). These findings suggest that BK-TPNs in this cortical area may be involved in sensory processing of noxious information from trigeminal regions.
在猫身上研究了单个皮层神经元对牙髓电刺激和牙髓内注射缓激肽的反应特性。从大脑皮层冠状回中部和前部记录牙髓驱动神经元（TPN）的活动。缓激肽敏感的牙髓驱动神经元（BK-TPN）位于冠状回前部3b区的IV层。这些神经元有一个大的面部皮肤感受野，并接受来自面部皮肤以及牙髓的伤害性输入。与对缓激肽不敏感的TPN（非BK-TPN）相比，BK-TPN对电刺激的阈值更高，潜伏期更长。这些发现表明，该皮层区域的BK-TPN可能参与三叉神经区域有害信息的感觉处理。
