Hu J W, Sessle B J
J Neurophysiol. 1984 Jul;52(1):39-53. doi: 10.1152/jn.1984.52.1.39.
The activity of 160 single neurons excited by electrical stimulation of the canine tooth pulp was studied in the subnucleus caudalis (medullary dorsal horn) and the subnucleus oralis of the trigeminal (V) spinal tract nucleus in chloralose-anesthetized cats to test the effects of natural as well as electrical stimulation of the tooth pulp. The neurons were functionally classified on the basis of their cutaneous receptive-field properties as low-threshold mechanoreceptive (LTM), wide dynamic range (WDR), or nociceptive specific (NS). The orofacial receptive-field properties and responses evoked by electrical stimulation of the tooth pulp indicated that the oralis and caudalis neurons examined had characteristics typical of those previously documented for oralis LTM neurons and for caudalis LTM, WDR, and NS neurons. Each neuron was also tested with cold and warm stimulation of the canine tooth, and some neurons were also tested for responsiveness to thermal stimulation of the premolar tooth or to mechanical and chemical stimuli delivered to the dentine of the canine tooth. Although all the neurons could be excited by electrical stimulation of the pulp, we found that the only neurons that consistently responded to thermal pulp stimuli were those located in the V subnucleus caudalis. Moreover, only those caudalis neurons that had been functionally classified as nociceptive (4 WDR and 21 NS neurons) showed this responsiveness. Heating of the canine or premolar tooth excited 24 of these 25 nociceptive neurons; cooling activated only 3, and none of the small number of neurons tested with mechanical and chemical stimulation of the dentine was excited. The response of the nociceptive neurons to heating of the tooth contrasted with the responses of the same neurons to pinching and heating of their cutaneous receptive field.(ABSTRACT TRUNCATED AT 400 WORDS)
在水合氯醛麻醉的猫中，研究了电刺激犬牙髓所兴奋的160个单神经元在三叉神经（V）脊髓束核的尾侧亚核（延髓背角）和口侧亚核中的活动，以测试牙髓自然刺激以及电刺激的效果。根据其皮肤感受野特性，将这些神经元功能分类为低阈值机械感受性（LTM）、广动力范围（WDR）或伤害性特异性（NS）。牙髓电刺激诱发的口面部感受野特性和反应表明，所检查的口侧和尾侧神经元具有先前记录的口侧LTM神经元以及尾侧LTM、WDR和NS神经元的典型特征。还对每个神经元进行了犬齿冷刺激和热刺激测试，一些神经元还测试了对前磨牙热刺激或对犬齿牙本质施加的机械和化学刺激的反应性。尽管所有神经元都可被牙髓电刺激兴奋，但我们发现，始终对牙髓热刺激有反应的唯一神经元是位于V尾侧亚核中的那些。此外，只有那些功能分类为伤害性的尾侧神经元（4个WDR和21个NS神经元）表现出这种反应性。犬齿或前磨牙加热使这25个伤害性神经元中的24个兴奋；冷却仅激活了3个，并且用牙本质机械和化学刺激测试的少数神经元均未被兴奋。伤害性神经元对牙齿加热的反应与同一神经元对其皮肤感受野捏夹和加热的反应形成对比。（摘要截短于400字）
