PHOSPHO1的新兴作用及其调控的磷脂稳态在代谢紊乱中的作用
The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders.
作者信息
Liu Yi, Wu Yingting, Jiang Mengxi
机构信息
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
出版信息
Front Physiol. 2022 Jul 26;13:935195. doi: 10.3389/fphys.2022.935195. eCollection 2022.
Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the role of PHOSPHO1 and its related phospholipid metabolites in regulating energy metabolism. We also examine mechanistic evidence of PHOSPHO1- and phospholipid-mediated regulation of mitochondrial and lipid droplets functions in the context of metabolic homeostasis, which could be potentially targeted for treating metabolic disorders.
新出现的证据表明，磷酸乙醇胺/磷酸胆碱磷酸酶1（PHOSPHO1），一种特定的磷酸乙醇胺和磷酸胆碱磷酸酶，参与能量代谢。在这篇综述中，我们描述了PHOSPHO1的结构和调节，以及目前关于PHOSPHO1及其相关磷脂代谢物在调节能量代谢中的作用的知识。我们还研究了在代谢稳态背景下，PHOSPHO1和磷脂介导的线粒体和脂滴功能调节的机制证据，这可能是治疗代谢紊乱的潜在靶点。
Zotero 插件