重新评估参与猪繁殖与呼吸综合征病毒附着和进入过程的宿主细胞因子，以制定抗病毒策略。
Reappraising host cellular factors involved in attachment and entry to develop antiviral strategies against porcine reproductive and respiratory syndrome virus.
作者信息
Li Rui, Qiao Songlin, Zhang Gaiping
机构信息
Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China.
出版信息
Front Microbiol. 2022 Jul 26;13:975610. doi: 10.3389/fmicb.2022.975610. eCollection 2022.
Abstract
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is a highly contagious disease that brings tremendous economic losses to the global swine industry. As an intracellular obligate pathogen, PRRSV infects specific host cells to complete its replication cycle. PRRSV attachment to and entry into host cells are the first steps to initiate the replication cycle and involve multiple host cellular factors. In this review, we recapitulated recent advances on host cellular factors involved in PRRSV attachment and entry, and reappraised their functions in these two stages, which will deepen the understanding of PRRSV infection and provide insights to develop promising antiviral strategies against the virus.
摘要
猪繁殖与呼吸综合征（PRRS）由猪繁殖与呼吸综合征病毒（PRRSV）引起，是一种高度传染性疾病，给全球养猪业带来巨大经济损失。作为一种细胞内专性病原体，PRRSV感染特定宿主细胞以完成其复制周期。PRRSV附着并进入宿主细胞是启动复制周期的第一步，涉及多个宿主细胞因子。在本综述中，我们概述了参与PRRSV附着和进入的宿主细胞因子的最新进展，并重新评估了它们在这两个阶段的功能，这将加深对PRRSV感染的理解，并为开发有前景的抗病毒策略提供思路。
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