Berry D J, Clarke L A
J Chromatogr. 1978 Sep 11;156(2):301-7. doi: 10.1016/s0021-9673(00)88318-1.
A specific and sensitive procedure for the determination of valproic acid at therapeutic concentrations in human plasma has been developed. The method involves a microscale extraction of the drug from acidified plasma into chloroform. Caproic acid is added as internal standard. The extract is subsequently analysed on a gas chromatography fitted with a flame ionisation detector, and quantitation achieved by the relative-peak-height technique.
已开发出一种用于测定人血浆中治疗浓度丙戊酸的特异且灵敏的方法。该方法包括将药物从酸化血浆中微量萃取至氯仿中。加入己酸作为内标。随后将萃取物在配有火焰离子化检测器的气相色谱仪上进行分析，并通过相对峰高技术进行定量。
