鼻渊通窍颗粒联合糠酸莫米松鼻喷雾剂对小儿变应性鼻炎临床症状的治疗作用
Therapeutic effect of Biyuan tongqiao granules combined with mometasone furoate nasal spray on clinical symptoms of children with allergic rhinitis.
作者信息
Ding Zan, Yang Nana, Cui Xin, Zhou De
机构信息
Department of ENT, Qingdao Women and Children's Hospital Qingdao 266034, Shandong, China.
出版信息
Am J Transl Res. 2022 Jul 15;14(7):5116-5123. eCollection 2022.
OBJECTIVE
To explore the clinical benefits of Biyuan Tongqiao granules (BTG) combined with mometasone furoate nasal spray (MFNS) on the symptoms of children with allergic rhinitis (AR).
METHODS
Seventy-eight children with AR who visited the Pediatric Department of our hospital from May 2019 to May 2020 were selected and randomly divided into the BTG group (treated with BTG alone), MFNS group (treated with MFNS alone), and combined group (children with the combined use of BTG and MFNS), with 26 cases in each group. The nasal symptoms and oculonasal symptoms were evaluated and observed at baseline and 2 months after treatment.
RESULTS
Children in the combination group had significantly lower total nasal symptom score (TNSS), total non-nasal symptom score (TNNSS) scores, and visual analogue scale (VAS) scores than those with BTG alone and MFNS alone (<0.05). The overall response rate was 69.23% in children with BTG alone, 80.77% in children with MFNS alone, and 92.31% in children with the combined treatment.
CONCLUSION
BTG combined with MFNS can improve the symptoms of sneezing and nasal congestion, which is better than single drug treatment.
目的
探讨鼻渊通窍颗粒（BTG）联合糠酸莫米松鼻喷雾剂（MFNS）治疗儿童变应性鼻炎（AR）的临床疗效。
方法
选取2019年5月至2020年5月在我院儿科就诊的78例AR患儿，随机分为BTG组（单纯使用BTG治疗）、MFNS组（单纯使用MFNS治疗）和联合组（BTG与MFNS联合使用），每组26例。在基线期及治疗2个月后对鼻症状和眼鼻症状进行评估和观察。
结果
联合组患儿的总鼻症状评分（TNSS）、总非鼻症状评分（TNNSS）及视觉模拟量表（VAS）评分均显著低于单纯使用BTG组和单纯使用MFNS组（<0.05）。单纯使用BTG组患儿的总有效率为69.23%，单纯使用MFNS组患儿的总有效率为80.77%，联合治疗组患儿的总有效率为92.31%。
结论
BTG联合MFNS可改善打喷嚏和鼻塞症状，效果优于单一药物治疗。
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