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变应性鼻炎 2020:实践参数更新。

Rhinitis 2020: A practice parameter update.

机构信息

Section of Allergy and Immunology, Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Saint Louis University, St Louis, Mo.

Department of Medicine, Nova Southeastern Allopathic Medical School, Fort Lauderdale, Fla.

出版信息

J Allergy Clin Immunol. 2020 Oct;146(4):721-767. doi: 10.1016/j.jaci.2020.07.007. Epub 2020 Jul 22.

Abstract

This comprehensive practice parameter for allergic rhinitis (AR) and nonallergic rhinitis (NAR) provides updated guidance on diagnosis, assessment, selection of monotherapy and combination pharmacologic options, and allergen immunotherapy for AR. Newer information about local AR is reviewed. Cough is emphasized as a common symptom in both AR and NAR. Food allergy testing is not recommended in the routine evaluation of rhinitis. Intranasal corticosteroids (INCS) remain the preferred monotherapy for persistent AR, but additional studies support the additive benefit of combination treatment with INCS and intranasal antihistamines in both AR and NAR. Either intranasal antihistamines or INCS may be offered as first-line monotherapy for NAR. Montelukast should only be used for AR if there has been an inadequate response or intolerance to alternative therapies. Depot parenteral corticosteroids are not recommended for treatment of AR due to potential risks. While intranasal decongestants generally should be limited to short-term use to prevent rebound congestion, in limited circumstances, patients receiving regimens that include an INCS may be offered, in addition, an intranasal decongestant for up to 4 weeks. Neither acupuncture nor herbal products have adequate studies to support their use for AR. Oral decongestants should be avoided during the first trimester of pregnancy. Recommendations for use of subcutaneous and sublingual tablet allergen immunotherapy in AR are provided. Algorithms based on a combination of evidence and expert opinion are provided to guide in the selection of pharmacologic options for intermittent and persistent AR and NAR.

摘要

这份过敏性鼻炎(AR)和非过敏性鼻炎(NAR)的综合实践参数为 AR 的诊断、评估、单药治疗和联合药物选择以及变应原免疫治疗提供了最新指导。文中回顾了有关局部 AR 的最新信息。咳嗽被强调为 AR 和 NAR 的常见症状。不推荐在常规评估鼻炎时进行食物过敏测试。鼻内皮质类固醇(INCS)仍然是持续性 AR 的首选单药治疗,但更多研究支持 INCS 与鼻内抗组胺药联合治疗在 AR 和 NAR 中具有附加益处。鼻内抗组胺药或 INCS 均可作为 NAR 的一线单药治疗。如果对替代疗法反应不足或不耐受,只有在 AR 中才应使用孟鲁司特。由于潜在风险,不建议使用 depot 注射皮质类固醇治疗 AR。尽管鼻内减充血剂通常应限制在短期使用以防止反弹性充血,但在某些情况下,可能会为接受包括 INCS 在内的治疗方案的患者提供鼻内减充血剂,使用时间最长可达 4 周。针刺和草药产品都没有足够的研究来支持其在 AR 中的应用。在妊娠的头三个月应避免使用口服减充血剂。提供了用于 AR 的皮下和舌下片剂变应原免疫治疗的使用建议。根据证据和专家意见的组合提供了算法,以指导间歇性和持续性 AR 和 NAR 中药物选择的选择。

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