Jacquez J A
Fed Proc. 1987 Jun;46(8):2477-80.
The observations in an experiment define a set of observational parameters that are functions of the basic kinetic parameters of the model of the system. The problem of identifiability is concerned with whether the observational parameters uniquely specify the basic kinetic parameters. As such, it depends only on the functional relation between the two levels of parameters and not on errors of observation and the estimation procedure. It should be checked before doing the experiment. Given initial estimates of the basic kinetic parameters, identifiability can be checked, in a local sense, from data generated by simulating the experiment on the model.
实验中的观测结果定义了一组观测参数，这些参数是系统模型基本动力学参数的函数。可识别性问题涉及观测参数是否唯一地指定基本动力学参数。因此，它仅取决于两级参数之间的函数关系，而不取决于观测误差和估计程序。应该在进行实验之前进行检查。给定基本动力学参数的初始估计值，可以从通过在模型上模拟实验生成的数据中，在局部意义上检查可识别性。
