Jacquez J A
Department of Physiology, University of Michigan Medical School, Ann Arbor.
JPEN J Parenter Enteral Nutr. 1991 May-Jun;15(3):55S-59S. doi: 10.1177/014860719101500355S.
In experiments on biological systems one often cannot measure all state variables (compartments). Given a particular experiment of that type, a basic kinetic parameter may have no effect on the observations; such a parameter is an insensible parameter for that experiment. A parameter may influence the observations and not be uniquely determinable; such a parameter is nonidentifiable for that experiment. Only identifiable parameters can be estimated uniquely, by that experiment. I review the basic theory to check identifiability for a nominal value of a parameter (local identifiability), and present some examples of problems that may arise in estimation.
在生物系统实验中，人们常常无法测量所有的状态变量（区室）。对于某一特定类型的实验，某个基本动力学参数可能对观测结果没有影响；这样的参数对于该实验来说是不可感知参数。一个参数可能会影响观测结果，但却无法唯一确定；这样的参数对于该实验来说是不可识别的。只有可识别的参数才能通过该实验唯一地估计出来。我回顾了用于检验参数标称值可识别性（局部可识别性）的基本理论，并给出了一些估计中可能出现的问题的例子。
