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流感病毒感染和免疫动物中免疫复合物成分的检测及组织定位

Detection and tissue localization of components of the immune complex in animals infected and immunized with influenza virus.

作者信息

Semkow R, Wilczyński J

出版信息

Acta Virol. 1979 Jan;23(1):52-8.

PMID:35959
Abstract

Mice previously vaccinated or convalescents after infection with mouse-adapted influenza virus were challenged by various routes with live or inactivated virus. The components of the immune complex (antigen-antibody-complement) could be detected by immunofluorescence in lungs, kidneys, and heart. The frequency of positive immunofluorescence reaction was related to serum antibody level and, to some extent, to the route the animals were challenged.

摘要

用鼠适应流感病毒预先接种过的小鼠或感染后康复的小鼠,通过不同途径用活病毒或灭活病毒进行攻击。免疫复合物(抗原 - 抗体 - 补体)的成分可通过免疫荧光在肺、肾和心脏中检测到。免疫荧光阳性反应的频率与血清抗体水平有关,并且在一定程度上与动物接受攻击的途径有关。

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引用本文的文献

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Influenza virus-induced immune complexes suppress alveolar macrophage phagocytosis.流感病毒诱导的免疫复合物抑制肺泡巨噬细胞的吞噬作用。
J Virol. 1984 May;50(2):287-92. doi: 10.1128/JVI.50.2.287-292.1984.
2
A new concept of the epidemic process of influenza A virus.甲型流感病毒流行过程的新概念。
Epidemiol Infect. 1987 Aug;99(1):5-54. doi: 10.1017/s0950268800066851.