Li Dongcheng, Ren Tengzhu, Li Hao, Liao Geng, Zhang Xiong
Department of Neurology, Affiliated Maoming People's Hospital, Southern Medical University, Maoming, China.
Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, China.
Front Neurol. 2022 Jul 26;13:945523. doi: 10.3389/fneur.2022.945523. eCollection 2022.
Cognitive impairment (CI) is a common complication of Parkinson's disease (PD). The major features of Parkinson's disease with cognitive impairment (PD-CI) include convergence of α-Synuclein (α-Syn) and Alzheimer's disease (AD)-like pathologies, neuroinflammation, and dysbiosis of gut microbiota. () is an important pathogen in periodontitis. Recent research has suggested a role of P. gingivalis and its virulence factor in the pathogenesis of PD and AD, in particular concerning neuroinflammation and deposition of α-Synuclein (α-Syn) and amyloid-β (Aβ). Furthermore, in animal models, oral could cause neurodegeneration through regulating the gut-brain axis, suggesting an oral-gut-brain axis might exist. In this article, we discussed the pathological characteristics of PD-CI and the role of in them.
认知障碍（CI）是帕金森病（PD）的常见并发症。帕金森病合并认知障碍（PD-CI）的主要特征包括α-突触核蛋白（α-Syn）与阿尔茨海默病（AD）样病理改变的汇聚、神经炎症以及肠道微生物群失调。（）是牙周炎的重要病原体。最近的研究表明牙龈卟啉单胞菌及其毒力因子在PD和AD的发病机制中起作用，特别是在神经炎症以及α-突触核蛋白（α-Syn）和淀粉样β蛋白（Aβ）沉积方面。此外，在动物模型中，口服（此处原文缺失具体内容）可通过调节肠-脑轴导致神经退行性变，提示可能存在口腔-肠道-脑轴。在本文中，我们讨论了PD-CI的病理特征以及（此处原文缺失具体内容）在其中的作用。
