Impact of rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population.

BACKGROUND

Ischemic stroke (IS) is a complex neurological disease affected by genetics and environment. Matrix metalloproteinase-2 () is involved in extracellular matrix (ECM) degradation, inflammation and angiogenesis to regulate the development and recovery of IS.

PURPOSES

The aim of this study was to explore the association of rs1053605, rs243849 and rs14070 in with the risk of IS in Chinese Shaanxi population.

METHODS

In this study, 677 IS patients and 681 normal controls were recruited. Rs1053605, rs243849 and rs14070 in were genotyped. Logistic regression analysis was applied to evaluate the association of rs1053605, rs243849 and rs14070 in with IS susceptibility and the association of environmental factors with genetic susceptibility to IS.

RESULTS

The results of the overall analysis demonstrated that rs14070 in significantly reduced the risk of IS in Chinese Shaanxi population (OR = 0.767, 95% CI = 0.619-0.952, = 0.016). Subgroup analysis illustrated that rs243849 in evidently increased the risk of IS among drinkers, while rs14070 in apparently reduced IS susceptibility among females, participants with aged >55, smokers and drinkers.

CONCLUSIONS

Collectively, rs243849 and rs14070 in were significantly associated with the risk of IS in Chinese Shaanxi population, and the effect of to IS may be associated with its genetic susceptibility.