The Relationship Between Variants and Ischemic Stroke Risk in the Population from Shaanxi Province in China.

BACKGROUND

Ischemic stroke (IS) was a multifactorial disease, which was the main cause of death and adult disability. Genetic factors cannot be ignored.

OBJECTIVE

The present study discussed the relationship between variants and the susceptibility of IS.

METHODS

Based on the Agena MassARRAY platform, we genotyped single nucleotide polymorphisms (SNPs) on the gene in 1345 participants (670 controls and 675 cases). We used logistic regression analysis to analyze the association of SNPs with the risk of IS in the Chinese population, with odds ratio (OR) and 95% confidence intervals (CIs). False-positive report probability (FPRP) detected false positives on the significant results. Besides, we detected the SNP-SNP interaction to predict IS risk by multi-factor dimensionality reduction (MDR) analysis.

RESULTS

In the total analysis, rs7975920 conferred an increased susceptibility to IS. After a stratified analysis by age and gender, the significant association between rs7975920 and IS risk was displayed in the subjects aged >55 years old and females. After stratified analysis by smoking and drinking, rs6598163 was related to the risk of IS in smokers and rs7975920 was associated with the risk of IS in smokers and was in correlation with IS risk in drinkers.

CONCLUSION

In short, we first observed that rs7975920 and rs6598163 were related to the risk of IS. The above results provided a theoretical basis for the elaboration of the role of MMP17 in IS in the Chinese population.