Zhang Lulu, Lu Yi, Ma Xiaoli, Xing Yuanxin, Sun Jinbo, Jia Yanfei
Research Center of Basic Medicine, Jinan Central Hospital, Shandong First Medical University, Jinan, China.
Research Center of Basic Medicine, Jinan Central Hospital, Shandong University, Jinan, China.
Front Mol Biosci. 2022 Jul 25;9:965924. doi: 10.3389/fmolb.2022.965924. eCollection 2022.
Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and increasing shreds of evidence demonstrate that G-quadruplexes have been associated with some important cellular events. Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigated to discover new effective anticancer drugs. Multiple modulations have been discovered between the secondary structure G-quadruplex and p53, probably further influencing the ferroptosis in cancer. G-quadruplex binds to ferric iron-related structures directly and may affect the p53 pathways as well as ferroptosis in cancer. In addition, G-quadruplex also interacts with p53 indirectly, including iron-sulfur cluster metabolism, telomere homeostasis, lipid peroxidation, and glycolysis. In this review, we summarized the latent interplay between G-quadruplex and p53 which focused mainly on ferroptosis in cancer to provide the potential understanding and encourage future studies.
铁死亡是一种由多种生物学过程触发的新型程序性细胞死亡形式，p53参与不同的铁死亡调控并作为关键调节因子发挥作用。DNA和RNA在富含GC的区域均可折叠成G-四链体，越来越多的证据表明G-四链体与一些重要的细胞事件相关。因此，对G-四链体的研究对于揭示其生物学功能至关重要。研究特定的G-四链体以发现新的有效抗癌药物。已发现G-四链体二级结构与p53之间存在多种调控关系，这可能进一步影响癌症中的铁死亡。G-四链体直接与三价铁相关结构结合，可能影响p53通路以及癌症中的铁死亡。此外，G-四链体还间接与p53相互作用，包括铁硫簇代谢、端粒稳态、脂质过氧化和糖酵解。在本综述中，我们总结了G-四链体与p53之间潜在的相互作用，主要聚焦于癌症中的铁死亡，以提供潜在的理解并鼓励未来的研究。
