Department of Radiology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou 510060, Guangdong Province, China.
Curr Med Imaging. 2023;19(8):955-961. doi: 10.2174/1573405618666220811120308.
Talaromyces marneffei (T. marneffei) is a heat-dimorphic fungus that commonly causes fatal opportunistic infections in immunocompromised patients, such as those with human immunodeficiency virus (HIV) infection.
In this case report we describe a case of intracranial infection of T. marneffei in a 42-year-old AIDS patient. Contrast enhanced MRI showed the left occipital lobe mass with ring enhancement, MRS showed elevated AAs and Lip waves in the mass. Surgical resection of the occipital lobe confirmed the lesion to be T. marneffei infection and possibly with tuberculosis after a pathological examination. Patients with intracranial ring enhancing space-occupying lesions on MRI should be considered for intracranial T. marneffei infection. Intracranial T. marneffei infection is relatively rarely reported and recently studied.
The MRI, in this case, suggests that ring enhancement mass and elevated AAs and Lip waves are helpful in the diagnosis of T. marneffei infection.
马尔尼菲青霉（Talaromyces marneffei，T. marneffei）是一种热双相真菌，通常在免疫功能低下的患者中引起致命的机会性感染，如人类免疫缺陷病毒（HIV）感染者。
在本病例报告中，我们描述了一例 42 岁艾滋病患者的颅内马尔尼菲青霉感染。增强磁共振成像（MRI）显示左枕叶肿块伴环状强化，磁共振波谱（MRS）显示肿块中氨基酸（AA）和脂质升高。枕叶的手术切除证实病变为马尔尼菲青霉感染，病理检查后可能合并结核。对于 MRI 上表现为颅内环状强化占位性病变的患者，应考虑颅内马尔尼菲青霉感染。颅内马尔尼菲青霉感染相对较少见且最近才得到研究。
本例中 MRI 提示环状强化肿块和 AA 及 Lip 升高有助于马尔尼菲青霉感染的诊断。
