Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Chem Commun (Camb). 2022 Aug 25;58(69):9686-9689. doi: 10.1039/d2cc03443c.
Catalytic enantioselective sulfenylation to construct diheteroatom-bearing carbon centres was achieved by employing chiral guanidine organocatalysts. This protocol provided a facile route towards the synthesis of α-fluoro-α-sulfenyl-β-ketoamides, azlactone adducts and α-sulfur-substituted amino acid derivatives in high yields with good to excellent enantioselectivities. A possible working mode was proposed to elucidate the chiral control of the process.
手性胍基有机催化剂实现了构建含二杂原子碳中心的催化对映选择性亚磺化反应。该方法为高收率、高对映选择性地合成α-氟-α-亚磺酰基-β-酮酰胺、氮丙啶加合物和α-硫取代氨基酸衍生物提供了一种简便的途径。提出了一种可能的作用模式来阐明该过程的手性控制。
