Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Chem Commun (Camb). 2010 Jul 14;46(26):4806-8. doi: 10.1039/c0cc00094a. Epub 2010 May 25.
Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).
首次发展了多功能有机催化剂用于α,β-不饱和酮和二芳基氧化膦的对映选择性磷酰-Michael 反应。光学活性产物具有季碳手性中心，产率高，对映选择性好（高达 98%ee）。
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