Kruger M, Brunko E, Dorchy H, Noël P
Diabete Metab. 1987 Apr;13(2):110-5.
In order to estimate the prevalence of diabetic neuropathy in proximal and distal peripheral nerves, femoral and peroneal motor conduction was evaluated in 61 diabetic children, adolescents and young adults whose type 1 diabetes had become clinically apparent before the age of 14 years. Femoral motor nerve conduction velocity (FMNCV) in diabetic patients (63.8 +/- 10.4 m/sec) was not significantly different from FMNCV in control subjects (65.6 +/- 7.1 m/sec). By contrast, peroneal motor nerve conduction velocity (PMNCV) in diabetic patients (50.2 +/- 6.9 m/sec) was significantly lower than in controls (54.1 +/- 3.5 m/sec). Distal motor weakness, sensory deficit and absent Achilles reflexes were strongly correlated to impaired motor conduction in peroneal and also in femoral nerve. Peroneal nerve abnormality was negatively correlated with HbA1 levels, while femoral nerve abnormality was positively correlated with the presence of retinopathy. This discrepancy is not fully understood. Age and duration of diabetes were unrelated to femoral or peroneal motor nerve conduction velocity. Our data emphasize the frequent occurrence of subclinical proximal neuropathy in diabetic children and adolescents.
为了评估近端和远端周围神经中糖尿病性神经病变的患病率，对61例1型糖尿病在14岁之前已出现临床症状的糖尿病儿童、青少年及年轻成年人进行了股神经和腓总神经运动传导评估。糖尿病患者的股神经运动神经传导速度（FMNCV）为（63.8±10.4米/秒），与对照组（65.6±7.1米/秒）相比无显著差异。相比之下，糖尿病患者的腓总神经运动神经传导速度（PMNCV）为（50.2±6.9米/秒），显著低于对照组（54.1±3.5米/秒）。远端运动无力、感觉缺陷和跟腱反射消失与腓总神经及股神经运动传导受损密切相关。腓总神经异常与糖化血红蛋白（HbA1）水平呈负相关，而股神经异常与视网膜病变的存在呈正相关。这种差异尚未完全明确。糖尿病的病程和年龄与股神经或腓总神经运动神经传导速度无关。我们的数据强调了糖尿病儿童和青少年中亚临床近端神经病变的频繁发生。
