Golubev Alexander S, Ostapchuk Petr N, Strelkova Tatiana V, Kagramanov Nikolai D, Suponitsky Kyrill Yu, Takazova Rina U, Chkanikov Nikolai D
A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation.
G.V. Plekhanov Russian University of Economics, 36 Stremyannyi Line, 117997, Moscow, Russia.
Org Biomol Chem. 2022 Aug 31;20(34):6809-6820. doi: 10.1039/d2ob01177h.
Substituted on the benzene ring 4-CF-2-chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF-2-chromenes have been investigated. It has been shown that 4-CF-2-chromenes are convenient precursors to 4-CF-coumarins.
根据施魏泽尔方法，由取代的2-(三氟乙酰基)苯酚和乙烯基三苯基氯化鏻制备了苯环上取代的4-CF-2-色烯，产率适中至优异。研究了芳环取代基的类型和位置对4-CF-2-色烯产率的影响。结果表明，4-CF-2-色烯是制备4-CF-香豆素的方便前体。
