Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India.
Carbohydr Res. 2024 Feb;536:109018. doi: 10.1016/j.carres.2023.109018. Epub 2023 Dec 23.
A proficient approach has been developed for the synthesis of substituted 2H-chromenes from C1-substituted glucal. The key step of our synthetic methodology was C-H activation in propylene carbonate solvent followed by 6π-electrocyclization aromatization in ethylene glycol as greener substitutes to toxic aprotic solvents, to obtain 2H-chromenes in a stepwise manner. The application of the developed methodology was further explored with the synthesis of a small library of substituted 2H-chromenes in good yields.
已经开发出一种从 C1 取代的葡糖醛酸出发合成取代 2H-色烯的有效方法。我们合成方法的关键步骤是在碳酸丙烯酯溶剂中进行 C-H 活化，然后在乙二醇中进行 6π-电环化芳构化，以绿色替代品替代有毒的非质子溶剂，以逐步方式获得 2H-色烯。所开发方法的应用进一步通过合成一系列取代的 2H-色烯的小文库得到了很好的探索。
