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基于生物的化学品交互式代谢图谱。

An interactive metabolic map of bio-based chemicals.

作者信息

Jang Woo Dae, Kim Gi Bae, Lee Sang Yup

机构信息

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

出版信息

Trends Biotechnol. 2023 Jan;41(1):10-14. doi: 10.1016/j.tibtech.2022.07.013. Epub 2022 Aug 10.

DOI:10.1016/j.tibtech.2022.07.013
PMID:35961799
Abstract

Metabolic engineering for the bio-based production of chemicals requires thorough understanding of metabolic reactions including enzymes, cofactors, reactants, and products. Here we present an interactive bio-based chemicals map that visualizes compounds, enzymes, and reaction pathways together with strategies for the production of chemicals by biological, chemical, and combined methods.

摘要

用于基于生物的化学品生产的代谢工程需要深入了解包括酶、辅因子、反应物和产物在内的代谢反应。在此,我们展示了一个交互式的基于生物的化学品图谱,该图谱将化合物、酶和反应途径与通过生物、化学和联合方法生产化学品的策略一同可视化呈现。

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