Baláz S, Sturdík E, Augustín J
Gen Physiol Biophys. 1987 Feb;6(1):65-77.
Expressions for time course of solute concentration in an arbitrary compartment of a biosystem were derived using simplifying assumptions of unidirectional transport and first order metabolism kinetics. The coefficients of the resulting exponential-summation function comprise, in addition to the volumes and the connecting areas of individual compartments, the rate parameters of the processes mentioned. The equations presented were verified using results obtained in drug potency testing.
利用单向运输和一级代谢动力学的简化假设，推导出生物系统任意隔室中溶质浓度随时间变化的表达式。所得指数求和函数的系数除了包括各个隔室的体积和连接面积外，还包括上述过程的速率参数。所给出的方程通过药物效价测试得到的结果进行了验证。
