Baláz S, Sturdík E, Augustín J
Biophys Chem. 1986 Jul;24(2):135-42. doi: 10.1016/0301-4622(86)80006-0.
The distribution of externally added low-molecular-weight solutes in systems comprising alternating membraneous and aqueous compartments with binding capacity is described for special conditions of unidirectional transport and linear (i.e., far from saturation) binding. The kinetics of the process valid for a certain time period is expressed as the sum of exponential functions of time, their number being equal to the number of compartments investigated. The coefficients of the equation involve the rate and equilibrium parameters of the process as well as the volumes and the connecting areas of individual compartments. The degenerated case resulting from the cellular structure of biosystems is also considered. The description is shown to agree well with the results of drug potency testing, bioactivity being used to monitor concentration of an effector in the receptor region.
描述了在具有结合能力的交替膜相和水相区室组成的系统中，外部添加的低分子量溶质在单向运输和线性（即远未饱和）结合的特殊条件下的分布情况。在特定时间段内有效的该过程动力学表示为时间的指数函数之和，其数量等于所研究的区室数量。该方程的系数涉及该过程的速率和平衡参数以及各个区室的体积和连接面积。还考虑了生物系统细胞结构导致的退化情况。结果表明，该描述与药物效力测试结果非常吻合，生物活性用于监测受体区域中效应物的浓度。
