Functional Neurosurgery Department, National Children's Health Center of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Department of Neurosurgery, First Medical Center, General Hospital of PLA, Beijing, China.
Neurol Sci. 2022 Nov;43(11):6471-6478. doi: 10.1007/s10072-022-06337-9. Epub 2022 Aug 13.
The effects of current conduction were researched to confirm that it can decrease focal epileptogenicity in patients with temporal lobe epilepsy (TLE).
Data from 13 patients with mesial TLE were collected. After no less than two habitual seizures were captured during stereo-electroencephalogram monitoring, current conduction was measured in the hippocampus to a homemade, zero potential circuit board. The interictal spike, ripple, fast ripple, and ictal epileptogenicity index (EI) changes were analyzed in the hippocampus, amygdala, and anterior and middle temporal neocortex regions.
Significant differences were found in the percentage of patients without spikes in the temporal neocortex between pre- and post-current conduction. Significant decreases in average ripple rates were found in the hippocampus and amygdala after current conduction. The percentage of fast ripple rate decrease in the hippocampus and amygdala was significantly higher than that in the temporal neocortex, and significant decreases were found in the fast ripple rate in the hippocampus from post- to pre-current conduction. Significant decreases were found in the EI values after current conduction in the amygdala and middle temporal lobe compared to the EI values before current conduction.
After current conduction in patients with TLE, the spike rate decreases in the hippocampus, amygdala, and anterior and middle temporal neocortex, the ripple rate decreases in the hippocampus and amygdala, the fast ripple decreases in the hippocampus, and the EI decreases in the amygdala and middle temporal neocortex. Current conduction can reduce epileptogenicity in the hippocampus in mesial TLE.
研究电流传导的影响，以确认其可降低颞叶癫痫（TLE）患者的致痫灶兴奋性。
收集了 13 例内侧 TLE 患者的数据。在立体脑电图监测中捕捉到至少两次习惯性发作后，对海马体进行电流传导测量，使用自制的零电位电路板。分析海马体、杏仁核以及前颞和中颞新皮层区域的棘波、棘慢波、快棘波和发作性癫痫指数（EI）变化。
在电流传导前后，颞叶新皮层无棘波的患者百分比存在显著差异。电流传导后，海马体和杏仁核的平均棘慢波率显著降低。海马体和杏仁核的快棘波率降低百分比明显高于颞叶新皮层，且电流传导后海马体的快棘波率明显降低。与电流传导前相比，电流传导后杏仁核和中颞叶的 EI 值显著降低。
在 TLE 患者中进行电流传导后，海马体、杏仁核和前颞及中颞新皮层的棘波率降低，海马体和杏仁核的棘慢波率降低，海马体的快棘波率降低，杏仁核和中颞叶的 EI 值降低。电流传导可降低内侧 TLE 患者的海马体致痫性。
